Medicine Overview

Indication

Muscle tightness, muscle cramping (spasms), muscle pain caused by spinal cord injury, stroke, cerebral palsy, multiple→ Show more

Administration

May be taken with or without food.

Adult Dose

OralSpasticityAdult: Initially, 25 mg daily increased gradually at 7-day intervals over 7 wk. Discontinue if no→ Show more

Child Dose

OralSpasticityChild: Initially, 0.5 mg/kg once daily, may increase gradually to 2 mg/kg 3-4 times daily. Max: 100 mg 4→ Show more

Contraindication

Active liver disease; acute muscle spasm; patients who use their spasticity to maintain posture or function. Lactation.

Mode of Action

Dantrolene has a direct action on skeletal muscle. It uncouples muscular contraction from excitation, probably by→ Show more

Precaution

Perform LFTs before and during treatment. Increased risk of liver injury in patients >30 yr, female patients especially→ Show more

Side Effect

Fatigue, muscle weakness/pain. GI disturbances, CNS effects, tachycardia, unstable BP, dyspnoea, drowsiness, rashes,→ Show more

Pregnancy Category Note

Pregnancy Category: C Lactation: enters breast milk/not recommended

Interaction

CNS depressants; oestrogens; calcium-channel blockers. CNS effects enhanced by alcohol or CNS depressants.

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The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should→ Show more