Endometriosis

Administration

Take at approximately the same time each day, with or without food

Adult Dose

Endometriosis Indicated for management of moderate-to-severe pain associated with endometriosis Initiate with 150 mg PO qDay for up to 24 months ... View More

Renal Dose

Renal impairment No dosage adjustment required with any degree of renal impairment or end-stage renal disease (including dialysis)

Contraindication

Pregnancy Known osteoporosis Severe hepatic impairment Coadministration of strong organic anion transporting polypeptide (OATP) 1B1 inhibitors ... View More

Mode of Action

Oral gonadotropin-releasing hormone (GnRH) receptor antagonist; inhibits endogenous GnRH signaling by binding competitively to GnRH receptors in the pit... View More

Precaution

May reduce the amount, intensity, or duration of menstrual bleeding, which may decrease the ability to recognize the occurrence of a pregnancy in a time... View More

Side Effect

>10% Hot flush or night sweats (24-36%) Headache (17-20%) Nausea (11-16%) 1-10% Insomnia (6-9%) Mood altered, mood swings (5-6%) Amenor... View More

Pregnancy Category Note

Pregnancy Contraindicated in pregnant women Drug exposure early in pregnancy may increase the risk of early pregnancy loss Discontinue elagolix i... View More